Critical Importance of In Vivo Amoxicillin and Cefotaxime Concentrations for Synergy in Treatment of Experimental Enterococcus faecalis Endocarditis-Reference-Cited by-同舟云学术

Critical Importance of In Vivo Amoxicillin and Cefotaxime Concentrations for Synergy in Treatment of Experimental Enterococcus faecalis Endocarditis

Published:1998-02 Issue:2 Volume:42 Page:468-470
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Join-Lambert Olivier¹,Mainardi Jean-Luc²,Cuvelier Catherine³,Dautrey Sophie³,Farinotti Robert³,Fantin Bruno¹,Carbon Claude¹

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale, Unité 13,1 and

2. Laboratoire de Microbiologie Médicale, Fondation-Hôpital Saint-Joseph, 75674 Paris Cedex 14,2 France

3. Service de Pharmacie Clinique et des Biomatériaux, Hôpital Bichat,3 75877 Paris Cedex 18, and

Abstract

ABSTRACT The synergy between amoxicillin and cefotaxime against two strains of Enterococcus faecalis (JH2-2 and 6370) in vitro and in rabbit endocarditis was investigated. In vitro synergy was obtained only when amoxicillin concentrations were below the MBC and when cefotaxime concentrations were above 1 μg/ml. No synergy was observed in vivo, because of the short period of time during which these pharmacologic requirements were achieved.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.2.468

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