Catabolite Repression in Inhibition of β-Galactosidase Synthesis by Escherichia coli in the Presence of Agents Producing Translation Errors

Author:

Artman M.1,Werthamer S.1,Gelb Phyllis1

Affiliation:

1. Section of Microbiology, Methodist Hospital of Brooklyn, Brooklyn, New York 11215

Abstract

Studies were made of the synthesis of β-galactosidase by Escherichia coli in the presence of 5-fluorouracil, streptomycin, and subinhibitory concentrations of chloramphenicol. The preferential inhibition of β-galactosidase synthesis observed in the presence of the above drugs was found to be caused by catabolite repression.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference19 articles.

1. Formation of an altered enzyme by Escherichia coli in the presence of neomycin;Bissell D. M.;J. Mol. Biol.,1965

2. The effect of amino acids on the ability of cyclic AMP to reverse catabolite repression in Escherichia coli;Broman R. L.;Biochem. Biophys. Res. Commun.,1970

3. Effets d'un analogue de l'uracile sur les proprietes d'une proteine enzymatique synthetisee en sa presence;Buassard A.;C. R. Acad. Sci.,1960

4. Reversal of mutant phenotypes by 5-fluorouracil: an approach to nucleotide sequences in messenger RNA. Proe;Champe S. P.;Nat. Acad. Sci. U.S.A.,1962

5. Mutants of Escherichia coli requiring methionine or vitamin B12;Davis B. D.;J. Bacteriol.,1950

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