Interactions with Commensal and Pathogenic Bacteria Induce HIV-1 Latency in Macrophages through Altered Transcription Factor Recruitment to the Long Terminal Repeat-Reference-Cited by-同舟云学术

Interactions with Commensal and Pathogenic Bacteria Induce HIV-1 Latency in Macrophages through Altered Transcription Factor Recruitment to the Long Terminal Repeat

Published:2021-03-10 Issue:7 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Viglianti Gregory A.¹,Planelles Vicente²,Hanley Timothy M.¹²^ORCID

Affiliation:

1. Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA

2. Department of Pathology, University of Utah Health, Salt Lake City, Utah, USA

Abstract

The major barrier toward the eradication of HIV-1 infection is the presence of a small reservoir of latently infected cells, which include CD4 + T cells and macrophages that escape immune-mediated clearance and the effects of antiretroviral therapy. There remain crucial gaps in our understanding of the molecular mechanisms that lead to transcriptionally silent or latent HIV-1 infection of macrophages.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02141-20

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