Relative DNA Methylation and Demethylation Efficiencies during Postnatal Liver Development Regulate Hepatitis B Virus Biosynthesis-Reference-Cited by-同舟云学术

Relative DNA Methylation and Demethylation Efficiencies during Postnatal Liver Development Regulate Hepatitis B Virus Biosynthesis

Published:2021-02-24 Issue:6 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Oropeza Claudia E.¹,Tarnow Grant¹,Taha Taha Y.¹^ORCID,Shalaby Rasha E.¹²,Hyde Marieta V.³,Maienschein-Cline Mark³,Green Stefan J.³^ORCID,McLachlan Alan¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

2. Department of Microbiology and Immunology, Faculty of Medicine, Tanta University, Tanta, Egypt

3. Research Resources Center, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

Abstract

HBV biosynthesis begins at birth and increases during early postnatal liver development in the HBV transgenic mouse model of chronic infection. The levels of viral RNA and DNA synthesis correlate with pioneer transcription factor FoxA transcript plus Tet methylcytosine dioxygenase-generated 5hmC abundance but inversely with Dnmt transcript levels and HBV DNA methylation.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02148-20

Reference68 articles.

1. Molecular biology of hepatitis B virus infection

2. Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells