GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a potent inhibitor of influenza virus in ferrets-Reference-Cited by-同舟云学术

GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a potent inhibitor of influenza virus in ferrets

Published:1995-11 Issue:11 Volume:39 Page:2583-2584
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ryan D M¹,Ticehurst J¹,Dempsey M H¹

Affiliation:

1. Glaxo Wellcome Research and Development Limited, Stevenage, United Kingdom.

Abstract

GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a novel viral neuraminidase (sialidase) inhibitor which, following intranasal administration in ferrets, is at least 100 to 1,000 times more effective than ribavirin and amantadine against influenza A and B viruses. It retains its activity even when treatments are delayed until 24 h postinfection and has no effect on the serum antibody response to infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.39.11.2583

Reference5 articles.

1. Efthymiopoulos C. P. Barrington J. Patel A. Harker A. Harris E. K. Hussey and A. Bye. 1994. Pharmacokinetics of the neuraminidase inhibitor 4-guanidino Neu5Ac2en (GG167) following intravenous intranasal and inhaled administration in man abstr. H70 p. 265. In Abstracts of the 34th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology Washington D.C.

2. Inhibition of influenza virus replication in mice by GG167 (4-guanidino-2,4-dideoxy-2,3- dehydro-N-acetylneuraminic acid) is consistent with extracellular activity of viral neuraminidase (sialidase);Ryan D. M.;Antimicrob. Agents Chemother.,1994

3. Smith W. C. H. Andrews and P. P. Laidlaw. 1933. A virus obtained from influenza patients. Lancet ii:66-68.

4. Rational design of potent sialidase-based inhibitors of influenza virus replication;von Itzstein M.;Nature (London),1993

5. 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro;Woods J. M.;Antimicrob. Agents Chemother.,1993

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