Enhanced activity of the combination of penicillin G and gentamicin against penicillin-resistant viridans group streptococci-Reference-Cited by-同舟云学术

Enhanced activity of the combination of penicillin G and gentamicin against penicillin-resistant viridans group streptococci

Published:1995-12 Issue:12 Volume:39 Page:2816-2818
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cercenado E¹,Díaz M D¹,Sánchez-Carrillo C¹,Vicente T¹,Bernaldo de Quirós J C¹

Affiliation:

1. Servicio de Microbiología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Abstract

We evaluated the effects of the combination of penicillin G and gentamicin against 10 penicillin-resistant bacteremic isolates of viridans group streptococci for which the MICs of penicillin were 4 to 64 micrograms/ml. In time-kill studies, the combination resulted in more killing of eight isolates for which the MICs of penicillin were from 8 to 64 micrograms/ml than any of the antimicrobial agents tested alone. In general, clearly enhanced antimicrobial activity was observed with the combination.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.39.12.2816

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