In vivo correlates for Streptococcus pneumoniae penicillin resistance in acute otitis media-Reference-Cited by-同舟云学术

In vivo correlates for Streptococcus pneumoniae penicillin resistance in acute otitis media

Published:1995-01 Issue:1 Volume:39 Page:271-272
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Gehanno P¹,Lenoir G¹,Berche P¹

Affiliation:

1. Service ORL, Hôpital Bichat-Claude Bernard, Paris, France.

Abstract

Eighty-four children suffering from acute otitis media caused by Streptococcus pneumoniae were treated prospectively with cefuroxime axetil suspension (30 mg/kg of body weight twice daily for 8 days). The high incidence of isolates with decreased susceptibilities to penicillin (42 of 84 isolates) allowed us to establish a relationship between clinical success and the penicillin MICs for pneumococcal isolates. It was found that cefuroxime axetil is clinically effective in the treatment of acute otitis media caused by penicillin-susceptible and penicillin-intermediate strains of S. pneumoniae. The results indicate that the risk of treatment failure with cefuroxime axetil was increased in children with otitis media caused by S. pneumoniae when the penicillin MIC were greater than or equal to 2 mg/liter.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.39.1.271

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