A Highly Restricted T-Cell Receptor Dominates the CD8 + T-Cell Response to Parvovirus B19 Infection in HLA-A*2402-Positive Individuals-Reference-Cited by-同舟云学术

A Highly Restricted T-Cell Receptor Dominates the CD8 + T-Cell Response to Parvovirus B19 Infection in HLA-A*2402-Positive Individuals

Published:2006-07 Issue:13 Volume:80 Page:6697-6701
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kasprowicz V.¹²,Isa A.³,Jeffery K.⁴,Broliden K.³,Tolfvenstam T.³,Klenerman P.²,Bowness P.¹

Affiliation:

1. MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford, United Kingdom

2. Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, Oxford University, Oxford, United Kingdom

3. Division of Clinical Virology, Karolinska Institute, Stockholm, Sweden

4. Department of Virology, John Radcliffe Hospital, Oxford, United Kingdom

Abstract

ABSTRACT Six of seven HLA-A*2402-positive individuals with acute parvovirus B19 infections made vigorous CD8-positive cytotoxic T-cell (CTL) responses to the viral epitope FYTPLADQF. All responders showed highly focused T-cell receptor (TCR) usage, using almost exclusively BV5.1. The BV5.1 TCR dominated the acute response, was maintained over time, and was also used by a remotely infected individual. Nine CTL clones and two oligoclonal lines obtained from three unrelated individuals used BV5.1, BJ2.1, and a conserved TCR CDR3 of nine amino acids. This commonly recognized epitope is likely important in long-term protective immunity and should be included in vaccine design.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02388-05

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