Affiliation:
1. Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204-5001
Abstract
ABSTRACT
Alanine racemases are ubiquitous prokaryotic enzymes providing the essential peptidoglycan precursor
d
-alanine. We present evidence that the enzymes from
Pseudomonas aeruginosa
and
Escherichia coli
function exclusively as homodimers. Moreover, we demonstrate that expression of a K35A Y235A double mutation of
dadX
in
E. coli
suppresses bacterial growth in a dominant negative fashion.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
42 articles.
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