Affiliation:
1. Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6
Abstract
ABSTRACT
Mutations in
mexR
yield a multidrug resistance phenotype in
nalB
mutants of
Pseudomonas aeruginosa
as a result of derepression of the
mexAB-oprM
multidrug efflux operon. MexR produced by several
nalB
strains carried single amino acid changes that compromised MexR stability or its ability to dimerize. Changes at residues L95 and R21, however, produced a stable MexR protein capable of dimerization and, thus, likely compromised DNA binding.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
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