Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli-Reference-Cited by-同舟云学术

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli

Published:1990-06 Issue:6 Volume:34 Page:1271-1272
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Yoshida H¹,Bogaki M¹,Nakamura M¹,Nakamura S¹

Affiliation:

1. Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.

Abstract

Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.34.6.1271

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