Transcriptional Analysis of the Principal Cell Division Gene, ftsZ , of Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Transcriptional Analysis of the Principal Cell Division Gene, ftsZ , of Mycobacterium tuberculosis

Published:2005-04 Issue:7 Volume:187 Page:2540-2550
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Roy Sougata¹,Ajitkumar Parthasarathi¹

Affiliation:

1. Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India

Abstract

ABSTRACT Multiple promoters drive the expression of the principal cell division gene, ftsZ , in bacterial systems. Primer extension analysis of total RNA from Mycobacterium tuberculosis and a Mycobacterium smegmatis transformant containing 1.117 kb of the upstream region of M. tuberculosis ftsZ and promoter fusion studies identified six ftsZ transcripts and their promoters in the ftsQ open reading frame and ftsQ - ftsZ intergenic region. The presence of multiple promoters reflects the requirement to maintain a high basal level of, or to differentially regulate, FtsZ expression during different growth conditions of the pathogen in vivo.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.187.7.2540-2550.2005

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