Antistaphylococcal activity of a cyclic peptide, LY146032, and vancomycin

Author:

Knapp C C,Washington J A

Abstract

The inhibitory and bactericidal activities of a novel cyclic peptide antibiotic, LY146032, and vancomycin against oxacillin-susceptible and oxacillin-resistant staphylococci were compared. The MICs for 90% of strains were two- to fourfold higher for vancomycin than for LY146032. MBC/MIC ratios for all strains were less than or equal to 2. In killing rate studies with four strains of staphylococci, there was no detectable growth in the presence of 4X the MIC of either LY146032 or vancomycin after 24 h of incubation.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference3 articles.

1. National Committee for Clinical Laboratory Standards. 1984. Performance standards for antimicrobial disk susceptibility tests 3rd ed. M2-M3. National Committee for Clinical Laboratory Standards Villanova Pa.

2. National Committee for Clinical Laboratory Standards. 1985. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically M7-A. National Committee for Clinical Laboratory Standards Villanova Pa.

3. MBCs for Staphylococcus aureus as determined by macrodilution and microdilution techniques;Shanholtzer C. J.;Antimicrob. Agents Chemother.,1984

Cited by 22 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The emerging role of computational design in peptide macrocycle drug discovery;Expert Opinion on Drug Discovery;2020-04-28

2. Roadmap for antibiotic discovery;Nature Microbiology;2016-05-26

3. Antimikrobielle Therapie;Klinische Infektiologie;2008

4. In Vivo Pharmacodynamic Activity of Daptomycin;Antimicrobial Agents and Chemotherapy;2004-01

5. Lipopeptide Antibiotics Produced by Streptomyces reseosporus and Streptomyces fradiae;Drugs and the Pharmaceutical Sciences;1997-07-03

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3