Gamma Interferon Fails To Induce Expression of Indoleamine 2,3-Dioxygenase and Does Not Control the Growth of Chlamydophila abortus in BeWo Trophoblast Cells-Reference-Cited by-同舟云学术

Gamma Interferon Fails To Induce Expression of Indoleamine 2,3-Dioxygenase and Does Not Control the Growth of Chlamydophila abortus in BeWo Trophoblast Cells

Published:2002-05 Issue:5 Volume:70 Page:2690-2693
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Entrican Gary¹,Wattegedera Sean¹,Chui Michelle¹,Oemar Lyn¹,Rocchi Mara¹²,McInnes Colin¹

Affiliation:

1. Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh EH26 0PZ

2. Department of Veterinary Clinical Studies, University of Edinburgh, Easter Bush, Edinburgh EH25 9RG, Scotland, United Kingdom

Abstract

ABSTRACT The BeWo trophoblast cell line does not constitutively express the tryptophan degrading enzyme indolamine 2,3-dioxygenase (IDO), nor can IDO expression be induced by gamma interferon. This correlates with the inability of BeWo cells to control the growth of Chlamydophila abortus , in contrast to effects observed in HeLa cells treated with gamma interferon.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.5.2690-2693.2002

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