Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis-Reference-Cited by-同舟云学术

Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis

Published:1995-11 Issue:22 Volume:177 Page:6688-6692
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Otten S L¹,Liu X¹,Ferguson J¹,Hutchinson C R¹

Affiliation:

1. School of Pharmacy, University of Wisconsin, Madison 53706, USA.

Abstract

The dnrQS genes from the daunorubicin producer Streptomyces peucetius were characterized by DNA sequencing, complementation analysis, and gene disruption. The dnrQ gene is required for daunosamine biosynthesis, and dnrS appears to encode a glycosyltransferase for the addition of the 2,3,6-trideoxy-3-aminohexose, daunosamine, to epsilon-rhodomycinone.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.177.22.6688-6692.1995

Reference47 articles.

1. Basic local alignment search tool;Altschul S. F.;J. Mol. Biol.,1990

2. PROSITE: a dictionary of sites and patterns in proteins;Bairoch A.;Nucleic Acids Res.,1992

3. Glycosylation of macrolide antibiotics in extracts of Streptomyces lividans;Cundliffe E.;Antimicrob. Agents Chemother.,1992

4. Nutrient effects on anthracycline production by Streptomyces peucetius in a defined medium;Dekleva M. L.;Can. J. Microbiol.,1985

5. Nucleotide sequence analysis of IS427 and its target sites in Agrobacterium tumefaciens T37;De Meirsman C.;Plasmid,1990

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