Author:
Caporaso N,Smith S M,Eng R H
Abstract
A fresh extract of garlic (Allium sativum) was administered orally to human volunteers. At intervals, serum and urine were collected and assayed for antifungal activity. The maximum tolerable dose was determined to be 25 ml of garlic extract. Larger amounts caused severe burning sensations in the esophagus and the stomach and vomiting. After oral ingestion of 25 ml of the extract, anticandidal and anticryptococcal activities were detected in undiluted serum 0.5 and 1 h after ingestion. No detectable antifungal activity was found in the excreted urine at any time after oral ingestion. Oral garlic is of limited value in the therapy of human fungal infections.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference7 articles.
1. Isolation, purification, identification, synthesis, and kinetics ofactivity of the anticandidal component of Allium sativum and a hypothesis for its mode of action;Barone F. E.;Mycologia,1977
2. Antimicrobial activity of crude juices of Allium ascalonicum, Allium ceps, and Allium sativum;Dankert J.;Zentralbl. Bakteriol. Parasitenkd. Infektionskr. Hyg. Abt. 1: Orig. Reihe A,1979
3. In vitro effect of aqueous extract of garlic (Allium sativum) on the growth and viability of Cryptococcus neoformans;FromtNug R. A.;Mycologia,1978
4. Garlic in cryptococcal meningitis;Hunan Medical College;Chin. Med. J.,1980
5. The fungicidal and fungistatic effects of an aqueous garlic extract on medically important yeast-like fungi;Moore G. S.;Mycologia,1977
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