Affiliation:
1. Departments of Anatomy and Microbiology, State University of New York, Upstate Medical Center, Syracuse, New York 13210
Abstract
Chick embryo chorioallantoic membrane, infected with the Blacksburg strain of Newcastle disease virus, was examined with an electron microscope to investigate the sequence of viral-induced host cell alterations. These were evident mostly in the endodermal epithelial cells lining the allantoic sac and were divided arbitrarily into three stages. Stage 1 was characterized by commencement of cell hypertrophy and hyperplasia and presence of fewer cytoplasmic inclusion bodies normally found in the cells; in stage 2, juxtanuclear nucleocapsid-glycogen aggregates appeared, and there were increased numbers of microvilli; stage 3 was characterized by increased cytoplasmic density and evidence of viral assembly and release. The morphological features of viral assembly and the virion are also described.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Reference26 articles.
1. The development of Newcastle disease virus in cells of the chorio-allantoic membrane as studied by thin sections;Bang F. B.;Bull. Johns Hopkins Hosp.,1953
2. Pathology of the cell infected with viruses-- morphological and biochemical aspects;Bang F. B.;Fed. Proc.,1955
3. Bang F. B. and A. Isaacs. 1957. Morphological aspects of virus cell relationships in influenza mumps and Newcastle (myxovirus) p. 249-257. In G. E. W. Wolstenholme and E. C. P. Millar (ed.) The nature of viruses. Ciba Found. Symp. Little Brown & Co. Boston.
4. Etude au microscope electronique de la morphogenese de la particule du virus Sendai;Berkaloff A.;J. Microsc.,1963
5. Etude pr 6- liminaire au microscope electronique du myxovirus parainfluenzae;Bonissol C.;Il. Ann. Inst. Pasteur,1968
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