Affiliation:
1. Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109-1048
Abstract
ABSTRACT
Dosage compensation equalizes X-linked gene products between the sexes. In
Caenorhabditis elegans
, the dosage compensation complex (DCC) binds both X chromosomes in XX animals and halves the transcription from each. The DCC is recruited to the X chromosomes by a number of loci,
rex
sites, and is thought to spread from these sites by an unknown mechanism to cover the rest of the chromosome. Here we describe a novel class of DCC-binding elements that we propose serve as “way stations” for DCC binding and spreading. Both
rex
sites and way stations comprise strong foci of DCC binding on the native X chromosome. However,
rex
sites maintain their ability to bind large amounts of DCC even on X duplications detached from the native X, while way stations do not. These results suggest that two distinct classes of DCC-binding elements facilitate recruitment and spreading of the DCC along the X chromosome.
Publisher
American Society for Microbiology
Subject
Cell Biology,Molecular Biology
Cited by
14 articles.
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