Modulation of particle uptake in Trichinella spiralis-infected mice

Abstract

Mice were infected with 170 Trichinella spiralis larvae, and their blood clearance of carbon particles was studied 4, 7, 13, 32, and 135 days later and compared with that of noninfected control mice. Clearance in mice with a 4-day-old infection was comparable to that in the controls; clearances in mice with 7- and 13-day-old infections were increasingly accelerated and significantly different from that in the controls; clearances in mice with 32- and 135-day old infections were proportionally inhibited. Trichinellosis in mice does not modulate phagocytosis during the intestinal stage, but causes enhancement during the migratory period and inhibition during the muscle phase.