Author:
Hirsch R L,Griffin D E,Winkelstein J A
Abstract
the pathogenesis of Sindbis virus infection was studied in congenic mice with normal levels of the fifth component of complement (C5) and in mice deficient in C5. Mice deficient in C5 had a higher mortality rate than mice with normal levels of C5 as well as impaired clearance of virus from their brain and feet.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference4 articles.
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2. The importance of an intact complement pathway in recovery from a primary viral infection: influenza in decomplemental and in C5-deficient mice;Hicks J. T.;J. Immunol.,1978
3. The effect of complement depletion on the course of Sindbis virus infection in mice;Hirsch R. L.;J. Immunol.,1978
4. The role of complement in viral infections. II. The clearance of Sindbis virus from the bloodstream and central nervous system of mice depleted of complement;Hirsch R. L.;J. Infect. Dis.,1980
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