Does Antibody Avidity to Plasmodium falciparum Merozoite Antigens Increase with Age in Individuals Living in Malaria-Endemic Areas?-Reference-Cited by-同舟云学术

Does Antibody Avidity to Plasmodium falciparum Merozoite Antigens Increase with Age in Individuals Living in Malaria-Endemic Areas?

Published:2021-05-17 Issue:6 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Tassi Yunga Samuel¹^ORCID,Bobbili Naveen¹,Lloyd Yukie M.¹^ORCID,Antallan Jovikka¹,Matsunaga Masako²,Quakyi Isabella³,Leke Rose F. G.⁴,Taylor Diane Wallace¹^ORCID

Affiliation:

1. Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA

2. Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA

3. Department of Biological, Environmental and Occupational Health Sciences, School of Public Health, College of Health Sciences, University of Ghana, Accra, Ghana

4. Faculty of Medicine and Biomedical Sciences, The Biotechnology Center, University of Yaoundé 1, Yaoundé, Cameroon

Abstract

High-avidity antibodies (Abs) are acquired after a few Plasmodium falciparum infections in low transmission areas, but it remains unclear if Ab avidity to different merozoite antigens increases with age in individuals with persistent antigenemia and, if so, when a fully mature Ab response occurs. The study used plasma samples collected between 1996 and 1998 from 566 individuals aged 4 to 84 years in Simbok, Cameroon, where residents received an estimated 1.6 infectious mosquito bites/person/night.

Funder

HHS | NIH | Fogarty International Center

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute on Minority Health and Health Disparities

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00522-20

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