Peptidyl-Prolyl Isomerase ppiB Is Essential for Proteome Homeostasis and Virulence in Burkholderia pseudomallei-Reference-Cited by-同舟云学术

Peptidyl-Prolyl Isomerase ppiB Is Essential for Proteome Homeostasis and Virulence in Burkholderia pseudomallei

Published:2019-10 Issue:10 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Bzdyl Nicole M.¹,Scott Nichollas E.²,Norville Isobel H.³,Scott Andrew E.³,Atkins Timothy³,Pang Stanley⁴,Sarovich Derek S.⁵^ORCID,Coombs Geoffrey⁴⁶,Inglis Timothy J. J.¹⁶⁷^ORCID,Kahler Charlene M.¹,Sarkar-Tyson Mitali¹

Affiliation:

1. Marshall Center for Infectious Diseases Research and Training, School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia

2. Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia

3. Defence Science Technology Laboratory (Dstl), Salisbury, United Kingdom

4. School of Veterinary and Life Sciences, Murdoch University, Murdoch, Australia

5. GeneCology Research Center, University of the Sunshine Coast, Sippy Downs, QLD, Australia

6. PathWest Laboratory Medicine WA, Perth, WA, Australia

7. School of Medicine, University of Western Australia, Perth, WA, Australia

Abstract

Burkholderia pseudomallei is the causative agent of melioidosis, a disease endemic to Southeast Asia and northern Australia. Mortality rates in these areas are high even with antimicrobial treatment, and there are few options for effective therapy. Therefore, there is a need to identify antibacterial targets for the development of novel treatments. Cyclophilins are a family of highly conserved enzymes important in multiple cellular processes.

Funder

Australian Government

North Atlantic Treaty Organization

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00528-19

Reference76 articles.

1. Ecology of Burkholderia pseudomallei and the interactions between environmental Burkholderia spp. and human–animal hosts

2. Melioidosis as an emerging global problem