Symptomatic Hyperbilirubinemia Secondary to Dapsone-Induced Hemolysis and Atazanavir Therapy

Author:

East Jeff,Blanton Lucas Scott

Abstract

ABSTRACTThe antiretroviral agent atazanavir is associated with mild asymptomatic hyperbilirubinemia. We report two cases of symptomatic hyperbilirubinemia attributed to atazanavir in conjunction with thePneumocystis jiroveciipneumonia prophylaxis agent dapsone. Symptoms and laboratory evidence of hemolysis resolved upon discontinuation of dapsone, enabling successful antiretroviral therapy. Symptomatic hyperbilirubinemia due to hemolytic anemia is a potential adverse event when using the combination of atazanavir and dapsone in the treatment of patients with the human immunodeficiency virus.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference12 articles.

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3. Atazanavir;Goldsmith;Drugs,2003

4. The predictive value of serum haptoglobin in hemolytic disease;Marchand;JAMA,1980

5. Hemolysis of red cells due to sulfone;Mayer;Ann. Intern. Med,1970

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