The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics-Reference-Cited by-同舟云学术

The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics

Published:2019-11-15 Issue:22 Volume:39 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Gal Jozsef¹^ORCID,Chen Jing¹,Na Duck-Young¹,Tichacek Laura¹,Barnett Kelly R.¹,Zhu Haining¹²

Affiliation:

1. Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA

2. Lexington VA Medical Center, Research & Development, Lexington, Kentucky, USA

Abstract

Stress granules (SGs) are ribonucleoprotein aggregates that form in response to stress conditions. The regulation of SG dynamics is not fully understood. Permanent pathological SG-like structures were reported in neurodegenerative diseases such as amyotrophic lateral sclerosis. The Ras GTPase-activating protein-binding protein G3BP1 is a central regulator of SG dynamics. We found that the lysine 376 residue (K376) of G3BP1, which is in the RRM RNA binding domain, was acetylated.

Funder

Office of the Vice President for Research, University of Kentucky [USA]

Department of Veterans Affairs [USA]

HHS | National Institutes of Health

American Cancer Society

Muscular Dystrophy Association

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00052-19