New Class of IMP Cyclohydrolases in Methanococcus jannaschii-Reference-Cited by-同舟云学术

New Class of IMP Cyclohydrolases in Methanococcus jannaschii

Published:2002-03 Issue:5 Volume:184 Page:1471-1473
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Graupner Marion¹,Xu Huimin¹,White Robert H.¹

Affiliation:

1. Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061-0308

Abstract

ABSTRACT The enzyme responsible for observed IMP cyclohydrolase activity in Methanococcus jannaschii was purified and sequenced: its genetic locus was found to correspond to gene MJ0626. The MJ0626 gene was cloned, and its protein product was expressed in Escherichia coli and shown to catalyze the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP. The enzyme has no sequence similarity to known enzymes, and its catalytic properties appear distinct from any characterized IMP cyclohydrolase. The purO gene for the enzyme is currently found only in the domain Archaea .

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.184.5.1471-1473.2002

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