Cytotoxic Cell Vacuolating Activity from Vibrio cholerae Hemolysin-Reference-Cited by-同舟云学术

Cytotoxic Cell Vacuolating Activity from Vibrio cholerae Hemolysin

Published:2000-03 Issue:3 Volume:68 Page:1700-1705
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Coelho Ana¹,Andrade João R. C.²,Vicente Ana Carolina P.³,Dirita Victor J.⁴

Affiliation:

1. Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ21944-970,1

2. Serviço de Microbiologia e Immunologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ20551-030,2 and

3. Departamento de Genética, Instituto Oswaldo Cruz, Rio de Janeiro, RJ21045-100,3 Brazil, and

4. Unit for Laboratory Animal Medicine and Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 481094

Abstract

ABSTRACT A Vibrio cholerae cytotoxin, designated VcVac, was found to cause vacuolation in Vero cells. It was originally detected in the pathogenic O1 Amazonia variant of V. cholerae and later shown to be produced in environmental strains and some El Tor strains. Comparison of VcVac production in various strains suggested that hemolysin was responsible for the vacuolating phenotype. Genetic experiments established a firm correlation between vacuolation and hemolysin production. The mammalian cell vacuolating activity of the V. cholerae hemolysin is a new property of this protein and points to a previously unknown type of interaction between V. cholerae and its host.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.3.1700-1705.2000

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