Intestinal Epithelial Cell Apoptosis following Cryptosporidium parvum Infection-Reference-Cited by-同舟云学术

Intestinal Epithelial Cell Apoptosis following Cryptosporidium parvum Infection

Published:2000-03 Issue:3 Volume:68 Page:1710-1713
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

McCole Declan F.¹,Eckmann Lars¹,Laurent Fabrice²,Kagnoff Martin F.¹

Affiliation:

1. Laboratory of Mucosal Immunology, Department of Medicine, University of California, San Diego, La Jolla, California 92093-0623,1 and

2. Laboratoire de Protozoologie, Centre INRA de Tours, 37380 Nouzilly, France2

Abstract

ABSTRACT Cryptosporidium parvum induces moderate levels of apoptosis of cultured human intestinal epithelial cells, which are maximal at 24 h after infection. Apoptosis is further increased in C. parvum -infected cells by inhibition of NF-κB. C. parvum infection also attenuates epithelial apoptosis induced by strongly proapoptotic agents. The data suggest C. parvum has developed strategies to limit apoptosis in order to facilitate its growth and maturation in the early period after epithelial cell infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.3.1710-1713.2000

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