Enhanced Susceptibility to Subcutaneous Abscess Formation and Persistent Infection around Catheters Is Associated with Sustained Interleukin-1β Levels

Author:

Boelens J. J.1,Zaat S. A. J.1,Murk J. L.1,Weening J. J.2,van der Poll T.3,Dankert J.1

Affiliation:

1. Department of Medical Microbiology,1

2. Department of Pathology,2 and

3. Department of Experimental Internal Medicine,3 Academic Medical Center, 1105 AZ, Amsterdam, The Netherlands

Abstract

ABSTRACT A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinylpyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1β (IL-1β) production was found. Apparently, sustained levels of IL-1β are associated with enhanced susceptibility to biomaterial-associated S. epidermidis infection.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference19 articles.

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2. Bisno A. L. Waldvogel F. A. Infections associated with indwelling medical devices 2nd ed. 1994 ASM Press Washington D.C.

3. Boelens J. J. S. A. Zaat J. Meeldijk and J. Dankert. Subcutaneous abscess formation around catheters induced by viable and non-viable Staphylococcus epidermidis as well as by small amounts of bacterial cell wall components. J. Biomed. Mater. Res. in press.

4. Boelens J. J. W. F. Tan J. Dankert and S. A. Zaat. Antibacterial activity of antibiotic-soaked polyvinylpyrrolidone-grafted silicon elastomer hydrocephalus shunts. J. Antimicrob. Chemother. in press.

5. Initiation of white cell activation during cardiopulmonary bypass: cytokines and receptors;Cameron D.;J. Cardiovasc. Pharmacol.,1996

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