In Vitro Activity of Mirincamycin (U24729A) against Plasmodium falciparum Isolates from Gabon-Reference-Cited by-同舟云学术

In Vitro Activity of Mirincamycin (U24729A) against Plasmodium falciparum Isolates from Gabon

Published:2010-01 Issue:1 Volume:54 Page:540-542
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Held Jana¹²,Westerman Richard³,Kremsner Peter G.¹²,Mordmüller Benjamin¹²

Affiliation:

1. Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany

2. Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon

3. Maldevco LTT, 1603 Evanston Ave., Kalamazoo, Michigan 49008

Abstract

ABSTRACT We assessed the in vitro activity of mirincamycin, a lincosamide antibiotic, against Plasmodium falciparum clinical isolates from Gabon. Growth was determined by HRP2 enzyme-linked immunosorbent assay using an adapted protocol with a prolonged incubation time (6 days) to account for antibiotic-induced delayed death. Mirincamycin's cis and trans isomers are more active (median 50% inhibitory concentrations [IC 50 s], 3.2 nM and 2.6 nM) than the comparator drugs clindamycin (IC 50 , 12 nM) and doxycycline (IC 50 , 720 nM), and therefore, further clinical development is promising.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01090-09

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