Author:
Jun Soo Youn,Jung Gi Mo,Son Jee-Soo,Yoon Seong Jun,Choi Yun-Jaie,Kang Sang Hyeon
Abstract
ABSTRACTIn spite of the high degree of amino acid sequence similarity between the newly discovered phage endolysin SAL-1 and the phage endolysin LysK, SAL-1 has an approximately 2-fold-lower MIC against severalStaphylococcus aureusstrains and higher bacterial cell-wall-hydrolyzing activity than LysK. The amino acid residue change contributing the most to this enhanced enzymatic activity is a change from glutamic acid to glutamine at the 114th residue.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
52 articles.
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