Leishmania major Promastigotes Inhibit Dendritic Cell Motility In Vitro-Reference-Cited by-同舟云学术

Leishmania major Promastigotes Inhibit Dendritic Cell Motility In Vitro

Published:2002-02 Issue:2 Volume:70 Page:1023-1026
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Jebbari Heather¹,Stagg Andrew J.¹,Davidson Robert N.²,Knight Stella C.¹

Affiliation:

1. Antigen Presentation Research Group, Department of Immunology

2. Department of Infectious Diseases and Tropical Medicine, Imperial College School of Medicine, Northwick Park Hospital, Harrow, London HA1 3UJ, United Kingdom

Abstract

ABSTRACT Using an in vitro transwell migration assay, we have demonstrated that products secreted by Leishmania major promastigotes inhibit the motility of dendritic cells (DC) by up to 93%. Inhibition was dose dependent and reversible. By inhibiting DC migration in vivo, L. major may therefore subvert DC from their potentially protective role during leishmaniasis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.2.1023-1026.2002

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