Antileishmanial Effect of Allopurinol-Reference-Cited by-同舟云学术

Antileishmanial Effect of Allopurinol

Published:1974-05 Issue:5 Volume:5 Page:469-472
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Pfaller Michael A.¹,Marr J. Joseph¹

Affiliation:

1. Departments of Medicine, Microbiology, and Pathology, Washington University School of Medicine, and Barnes Hospital, St. Louis, Missouri 63110

Abstract

Allopurinol (4-hydroxypyrazolo[3,4-d]pyrimidine) has been shown to inhibit the growth of Leishmania braziliensis in vitro at concentrations which are attainable in human tissues and body fluids. This compound is believed to act by interdicting the de novo synthesis of pyrimidines, probably through the formation of allopurinol ribotide. Its lack of toxicity makes it a potential candidate for animal experimentation and it may serve as a prototype for other agents with similar mechanisms of action.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.5.5.469

Reference18 articles.

1. Mechanism of allopurinol-mediated inhibition of pyrimidine biosynthesis;Beardmore T. D.;J. Lab. Clin. Med.,1971

2. The action in vitro of diamidines and other compounds on Leishmania donovani;Collier H.;Ann. Trop. Med. Parasitol.,1946

3. The metabolism of Leishmania donovani in culture;Crowther S.;Biochem. J.,1954

4. Effects of long-chain mono- and dicarboxylic acids on the pteridine requirement of Crithidia;Dewey V. C.;Arch. Biochem. Biophys.,1966

5. Metabolic studies of allopurinol, an inhibitor of xanthine oxidase;Elion G. B.;Biochem. Pharmacol.,1966

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