Microbiological Agar Diffusion Assay for Metronidazole Concentrations in Serum

Author:

Levison Matthew E.1

Affiliation:

1. Department of Medicine, Medical College of Pennsylvania, Philadelphia, Pennsylvania 19129

Abstract

An agar diffusion method using paper disks on plates seeded with Clostridium perfringens and incubated anaerobically to assay serum levels of metronidazole is described. The lowest serum metronidazole concentration that could be measured was 0.7 μg/ml, and the average error was 4% for 5 μg/ml. This assay could measure metronidazole in the presence of gentamicin or in the presence of penicillin, with the use of penicillinase incorporated into the assay plates, or in presence of penicillin, methicillin, and cephalothin with prior exposure of the specimen to beta-lactamase.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference3 articles.

1. Absorption and excretion of metronidazole-Part I. Serum concentration and urinary excretion after oral administration;Kane P. O.;Brit. J. Vener. Dis.,1961

2. Rapid microassay of gentamicin, kanamycin, neomycin, streptomycin, and vancomycin in serum or plasma;Sabath L. D.;J. Lab. Clin. Med.,1971

3. Metronidazole versus anaerobes-in vitro data and initial clinical observations;Tally F. P.;Calif. Med.,1972

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