Sulfadiazine Sodium Ameliorates the Metabolomic Perturbation in Mice Infected with Toxoplasma gondii-Reference-Cited by-同舟云学术

Sulfadiazine Sodium Ameliorates the Metabolomic Perturbation in Mice Infected with Toxoplasma gondii

Published:2019-10 Issue:10 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zhou Chun-Xue¹²,Gan Yun¹,Elsheikha Hany M.³,Chen Xiao-Qing⁴,Cong Hua²,Liu Qing⁵,Zhu Xing-Quan¹

Affiliation:

1. State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province, People’s Republic of China

2. Department of Parasitology, Shandong University School of Basic Medicine, Jinan, Shandong Province, People’s Republic of China

3. Faculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, University of Nottingham, Loughborough, United Kingdom

4. Jiangxi Provincial Key Laboratory for Animal Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi Province, People’s Republic of China

5. College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi Province, People’s Republic of China

Abstract

In this study, we analyzed the global metabolomic changes associated with Toxoplasma gondii infection in mice in the presence or absence of sulfadiazine sodium (SDZ) treatment. BALB/c mice were infected with T. gondii GT1 strain and treated orally with SDZ (250 μg/ml in water) for 12 consecutive days. Mice showed typical manifestations of illness at 20 days postinfection (dpi); by 30 dpi, 20% had survived and developed latent infection.

Funder

Basal Research Fund of Shandong University

International Science and Technology Cooperation Project of Gansu Provincial Key Research and Development Program

Agricultural Science and Technology Innovation Program

Natural Science Foundation of Shandong Province

State Key Laboratory of Veterinary Etiological Biology

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00312-19