Pharmacokinetic-Pharmacodynamic Evaluation of Ertapenem for Patients with Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia-Reference-Cited by-同舟云学术

Pharmacokinetic-Pharmacodynamic Evaluation of Ertapenem for Patients with Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia

Published:2019-06 Issue:6 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bader J. C.¹,Lakota E. A.¹,Dale G. E.²,Sader H. S.³,Rex J. H.⁴,Ambrose P. G.¹,Bhavnani S. M.¹

Affiliation:

1. Institute for Clinical Pharmacodynamics, Inc., Schenectady, New York, USA

2. Polyphor, Ltd., Allschwil, Switzerland

3. JMI Laboratories, North Liberty, Iowa, USA

4. F2G, Ltd., Manchester, United Kingdom

Abstract

Ertapenem provides activity against many pathogens commonly associated with hospital-acquired and ventilator-associated bacterial pneumoniae (HABP and VABP, respectively), including methicillin-susceptible Staphylococcus aureus and numerous Gram-negative pathogens with one major gap in coverage, Pseudomonas aeruginosa . Pharmacokinetic-pharmacodynamic (PK-PD) target attainment analyses were conducted to evaluate ertapenem against the most prevalent Enterobacteriaceae causing HABP/VABP.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00318-19

Reference43 articles.

1. Estimating Health Care-Associated Infections and Deaths in U.S. Hospitals, 2002

2. Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies

3. Economic Impact of Ventilator-Associated Pneumonia in a Large Matched Cohort

4. Microbial Etiologies of Hospital‐Acquired Bacterial Pneumonia and Ventilator‐Associated Bacterial Pneumonia

5. Multidrug Resistance among Gram-Negative Pathogens That Caused Healthcare-Associated Infections Reported to the National Healthcare Safety Network, 2006–2008

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