Effects of Altering Aminoglycoside Structures on Bacterial Resistance Enzyme Activities-Reference-Cited by-同舟云学术

Effects of Altering Aminoglycoside Structures on Bacterial Resistance Enzyme Activities

Published:2011-07 Issue:7 Volume:55 Page:3207-3213
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Green Keith D.¹,Chen Wenjing²¹,Garneau-Tsodikova Sylvie³²¹

Affiliation:

1. Life Sciences Institute, 210 Washtenaw Ave., Ann Arbor Michigan 48109-2216

2. Chemical Biology Doctoral Program, 210 Washtenaw Ave., Ann Arbor Michigan 48109-2216

3. Department of Medicinal Chemistry, 210 Washtenaw Ave., Ann Arbor Michigan 48109-2216

Abstract

ABSTRACT Aminoglycoside-modifying enzymes (AMEs) constitute the most prevalent mechanism of resistance to aminoglycosides by bacteria. We show that aminoglycosides can be doubly modified by the sequential actions of AMEs, with the activity of the second AME in most cases unaffected, decreased, or completely abolished. We demonstrate that the bifunctional enzyme AAC(3)-Ib/AAC(6′)-Ib′ can diacetylate gentamicin. Since single acetylation does not always inactivate the parent drugs completely, two modifications likely provide more-robust inactivation in vivo .

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00312-11

Reference33 articles.

1. Properties of a Bifunctional Bacterial Antibiotic Resistance Enzyme That Catalyzes ATP-Dependent 2‘‘-Phosphorylation and Acetyl-CoA-Dependent 6‘-Acetylation of Aminoglycosides

2. Domain−Domain Interactions in the Aminoglycoside Antibiotic Resistance Enzyme AAC(6‘)-APH(2‘ ‘)

3. Structural basis for aminoglycoside inhibition of bacterial ribosome recycling

4. X-ray structure of the AAC(6')-Ii antibiotic resistance enzyme at 1.8 A resolution; examination of oligomeric arrangements in GNAT superfamily members

5. Structural Analyses of Nucleotide Binding to an Aminoglycoside Phosphotransferase,

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