Inhibition of Plasmodium falciparum Growth In Vitro and Adhesion to Chondroitin-4-Sulfate by the Heparan Sulfate Mimetic PI-88 and Other Sulfated Oligosaccharides-Reference-Cited by-同舟云学术

Inhibition of Plasmodium falciparum Growth In Vitro and Adhesion to Chondroitin-4-Sulfate by the Heparan Sulfate Mimetic PI-88 and Other Sulfated Oligosaccharides

Published:2006-08 Issue:8 Volume:50 Page:2850-2852
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Adams Yvonne¹²,Freeman Craig³,Schwartz-Albiez Reinhard⁴,Ferro Vito⁵,Parish Christopher R.³,Andrews Katherine T.²

Affiliation:

1. Hygiene-Institut, Abteilung Parasitologie, Universität Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany

2. Clinical Tropical Medicine Laboratory and the Australian Centre for International and Tropical Health and Nutrition (ACITHN), Queensland Institute of Medical Research, QLD 4006, Australia

3. Cancer and Vascular Biology Group, Division of Immunology and Genetics, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia

4. Deutsches Krebsforschungszentrum, Tumorimmunologie, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany

5. Drug Design Group, Progen Industries Ltd., Darra, QLD 4076, Australia

Abstract

ABSTRACT A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 μM) and demonstrated modest adhesion inhibition to cell surface CSA.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00313-06

Reference26 articles.

1. Adams, Y., S. L. Smith, R. Schwartz-Albiez, and K. T. Andrews. 2005. Carrageenans inhibit the in vitro growth of Plasmodium falciparum and cytoadhesion to CD36. Parasitol. Res.97:290-294.

2. Aitman, T. J., L. D. Cooper, P. J. Norsworthy, F. N. Wahid, J. K. Gray, B. R. Curtis, P. M. McKeigue, D. Kwiatkowski, B. M. Greenwood, R. W. Snow, A. V. Hill, and J. Scott. 2000. Malaria susceptibility and CD36 mutation. Nature405:1015-1016.

3. Inhibition of Chondroitin-4-Sulfate-Specific Adhesion of Plasmodium falciparum -Infected Erythrocytes by Sulfated Polysaccharides

4. Andrews, K. T., A. Walduck, M. J. Kelso, D. P. Fairlie, A. Saul, and P. G. Parsons. 2000. Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents. Int. J. Parasitol.30:761-768.

5. Barragan, A., D. Spillmann, P. G. Kremsner, M. Wahlgren, and J. Carlson. 1999. Plasmodium falciparum: molecular background to strain-specific rosette disruption by glycosaminoglycans and sulfated glycoconjugates. Exp. Parasitol.91:133-143.

Cited by 23 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Enhanced Antimalarial and Antisequestration Activity of Methoxybenzenesulfonate-Modified Biopolymers and Nanoparticles for Tackling Severe Malaria;ACS Infectious Diseases;2024-01-25

2. Not Just Anticoagulation—New and Old Applications of Heparin;Molecules;2022-10-17

3. 3D Organoid Assay of the Impact of Infected Erythrocyte Adhesion on the Blood–Brain Barrier;Methods in Molecular Biology;2022

4. Engineered Sulfated Polysaccharides for Biomedical Applications;Advanced Functional Materials;2021-02-28

5. Heparin: new life for an old drug;Nanomedicine;2017-07