Metabolites Involved in Aerobic Degradation of the A and B Rings of Estrogen-Reference-Cited by-同舟云学术

Metabolites Involved in Aerobic Degradation of the A and B Rings of Estrogen

Published:2019-02 Issue:3 Volume:85 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Wu Kan¹,Lee Tzong-Huei²,Chen Yi-Lung¹³,Wang Yu-Sheng¹,Wang Po-Hsiang¹⁴,Yu Chang-Ping⁵,Chu Kung-Hui⁶,Chiang Yin-Ru¹

Affiliation:

1. Biodiversity Research Center, Academia Sinica, Taipei, Taiwan

2. Institute of Fisheries Science, National Taiwan University, Taipei, Taiwan

3. State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, China

4. Earth-Life Science Institute, Tokyo Institute of Technology, Tokyo, Japan

5. Graduate Institute of Environmental Engineering, National Taiwan University, Taipei, Taiwan

6. Zachry Department of Civil Engineering, Texas A&M University, College Station, Texas, USA

Abstract

Estrogens, often detected in surface waters worldwide, have been classified as endocrine disrupting chemicals and carcinogens. Bacterial degradation is crucial for removing natural estrogens from natural and engineered ecosystems; however, current knowledge regarding the biochemical mechanisms and catabolic enzymes involved in estrogen biodegradation is very limited. Our estrogen metabolite profile and genomic analyses on estrone-degrading bacteria enabled us to characterize the aerobic estrogen degradation pathway. The results greatly expand our understanding of microbial steroid degradation. In addition, the characteristic metabolites, dead-end products, and degradation genes can be used as biomarkers to investigate the fate and biodegradation potential of estrogens in the environment.

Funder

Ministry of Science and Technology, Taiwan

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.02223-18

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