Pharmacogenomics of Cytauxzoon felis Cytochrome b : Implications for Atovaquone and Azithromycin Therapy in Domestic Cats with Cytauxzoonosis-Reference-Cited by-同舟云学术

Pharmacogenomics of Cytauxzoon felis Cytochrome b : Implications for Atovaquone and Azithromycin Therapy in Domestic Cats with Cytauxzoonosis

Published:2013-09 Issue:9 Volume:51 Page:3066-3069
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Schreeg Megan E.¹,Marr Henry S.¹,Tarigo Jaime¹,Cohn Leah A.²,Levy Michael G.¹,Birkenheuer Adam J.¹

Affiliation:

1. North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA

2. University of Missouri College of Veterinary Medicine, Columbia, Missouri, USA

Abstract

ABSTRACT Cytauxzoon felis , an emerging virulent protozoan parasite that infects domestic cats, is treated with atovaquone and azithromycin (A&A). Atovaquone targets parasite cytochrome b . We characterized the C. felis cytochrome b gene ( cytb ) in cats with cytauxzoonosis and found a cytb genotype that was associated with survival in A&A-treated cats.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01407-13

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