Affiliation:
1. Biology Department, Montana State University, Bozeman, Montana 59715
Abstract
T4-infected
Escherichia coli
cells briefly exposed to rifampin, or to rifampin plus chloramphenicol, were capable of protein synthesis for some time after removal of the antibiotics, although ribonucleic acid synthesis was irreversibly inhibited. Partially completed peptides trapped on polysomes by high levels of chloramphenicol were eventually completed after removal of the drug, as demonstrated by subjecting labeled peptides from appropriate polysome regions to polyacrylamide disc gel electrophoresis. Thus, the effect of the drug appears to be reversible on the molecular as well as the cellular level.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
5 articles.
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1. Bioavailability of Antibiotics and Their Toxicity;Emerging Contaminants and Associated Treatment Technologies;2020
2. Tetracyclines, Glycylcyclines, and Chloramphenicol;Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases;2015
3. Clindamycin, Metronidazole, and Chloramphenicol;Mayo Clinic Proceedings;1999-08
4. Chloramphenicol;Journal of Gynecologic Surgery;1992-01
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