Measles-specific antibodies in sera and cerebrospinal fluids of patients with multiple sclerosis

Abstract

Immunoprecipitation methods were used to analyze sera and cerebrospinal fluids from patients with multiple sclerosis for measles virus-specific antibodies. The sera contained antibodies against all virus antigens except the matrix polypeptide. Of the nine cerebrospinal fluids investigated, two contained undetectable levels of measles-specific antibodies, four contained antibodies against the nucleocapsid and another internal antigen, and three contained antibodies against the surface antigens as well as the internal antigens.