Affiliation:
1. Medicine Branch, National Cancer Institute, Bethesda, Maryland 20014
Abstract
Kasugamycin is an aminoglycosidic antibiotic which was initially reported as being of potential use against
Pseudomonas
. Our evaluation of this antibiotic does not confirm this expectation. The median minimal inhibitory concentration (MIC) of the
Pseudomonas
strains tested was 250 μg/ml and the bactericidal level was 500 μg/ml. Kasugamycin was found to be slightly more active in a more basic medium (Mycin Assay broth) in which the median MIC for 11
Pseudomonas
strains was 125 μg/ml. Kasugamycin manifests a modest degree of serum binding. Kasugamycin did not have any appreciable effect against a variety of bacteria tested. The only exceptions were several species of gram-negative bacteria, against which more satisfactory antibiotics already exist. Further evaluation of kasugamycin for potential human use as an antipseudomonal agent does not appear warranted.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
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