Descriptive, Retrospective Study of the Clinical Characteristics of Asymptomatic COVID-19 Patients

Author:

Han Huan1,Xu Zaichao23,Cheng Xiaoming4,Zhong Youquan23,Yuan Li5,Wang Fubing5,Li Yan6,Liu Fang7,Jiang Yingan8,Zhu Chengliang1,Xia Yuchen23ORCID

Affiliation:

1. Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China

2. State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, China

3. Hubei Province Key Laboratory of Allergy and Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan, China

4. Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA

5. Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China

6. Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

7. State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China

8. Department of Infectious Diseases, Renmin Hospital, Wuhan University, Wuhan, China

Abstract

Asymptomatic transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a potential problem for pandemic control through public health strategies. Our results demonstrate that asymptomatic COVID-19 patients have better outcomes than symptomatic patients. This may have been due to more active cellular immune responses and normal liver function. Since asymptomatic patients have no clinical symptoms which can easily prevent timely diagnosis and treatment, they may cause a greater risk of virus transmission than symptomatic patients, which poses a major challenge to infection control. Evidence suggests that nonpharmaceutical public health interventions, like social distancing and face mask ordinances, play important roles in the control of COVID-19. Looking forward, it may be necessary to proceed cautiously while reopening businesses in areas of epidemicity to prevent potential waves of COVID-19 in the future.

Funder

MOE | Fundamental Research Funds for the Central Universities

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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