Transcriptomic Signatures of Tacaribe Virus-Infected Jamaican Fruit Bats

Author:

Gerrard Diana L.1,Hawkinson Ann2,Sherman Tyler2,Modahl Cassandra M.3,Hume Gretchen2,Campbell Corey L.4,Schountz Tony4,Frietze Seth1ORCID

Affiliation:

1. Department of Medical Laboratory and Radiation Sciences and Cell, Molecular, and Biomedical Sciences Program, University of Vermont, Burlington, Vermont, USA

2. School of Biological Sciences, University of Northern Colorado, Greeley, Colorado, USA

3. Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore

4. Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA

Abstract

As reservoir hosts of viruses associated with human disease, little is known about the interactions between bats and viruses. Using Jamaican fruit bats infected with Tacaribe virus (TCRV) as a model, we characterized the gene expression responses to infection in different tissues and identified pathways involved with the response to infection. This report is the most detailed gene discovery work in the species to date and the first to describe immune gene expression responses in bats during a pathogenic viral infection.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference79 articles.

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2. IUCN . 2015. Table 4a. Number of species in each IUCN Red List category in each major animal taxonomic group (class, order). IUCN Red List version 2015.1. IUCN, Cambridge, United Kingdom. http://www.iucnredlist.org . Accessed 11 June 2015.

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