Original Antigenic Sin: the Downside of Immunological Memory and Implications for COVID-19-Reference-Cited by-同舟云学术

Original Antigenic Sin: the Downside of Immunological Memory and Implications for COVID-19

Published:2021-04-28 Issue:2 Volume:6 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Brown Eric L.¹^ORCID,Essigmann Heather T.¹

Affiliation:

1. Center for Infectious Disease, Division of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center, Houston, Texas, USA

Abstract

The concept of original antigenic sin (OAS) was put forth many years ago to explain how humoral memory responses generated against one set of antigens can affect the nature of antibody responses elicited to challenge infections or vaccinations containing a similar but not identical array of antigens. Here, we highlight the link between OAS and the germinal center reaction (GCR), a process unique to activated B cells undergoing somatic hypermutation and class switch recombination.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00056-21

Reference34 articles.

1. On the doctrine of original antigenic sin;Francis T;Proc Am Philos Soc,1960

2. From Original Antigenic Sin to the Universal Influenza Virus Vaccine

3. Original Antigenic Sin: How First Exposure Shapes Lifelong Anti–Influenza Virus Immune Responses

4. Immune history and influenza virus susceptibility

5. Overcoming Barriers in the Path to a Universal Influenza Virus Vaccine

Cited by 34 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Original antigenic sin: A potential double-edged effect for vaccine improvement;Biomedicine & Pharmacotherapy;2024-09

2. Non-cross-reactive epitopes dominate the humoral immune response to COVID-19 vaccination – kinetics of plasma antibodies, plasmablasts and memory B cells;Frontiers in Immunology;2024-05-14

3. Waning immunity and IgG4 responses following bivalent mRNA boosting;Science Advances;2024-02-23

4. Harnessing preexisting influenza virus-specific immunity increases antibody responses against SARS-CoV-2;Journal of Virology;2024-02-20

5. Ethical Vaccine Recommendations in the Context of Tenuous Data: Honesty is the Best Policy;The American Journal of Bioethics;2023-10-03