A Mouse Model for Infection with Enterovirus A71 in Small Extracellular Vesicles-Reference-Cited by-同舟云学术

A Mouse Model for Infection with Enterovirus A71 in Small Extracellular Vesicles

Published:2020-08-26 Issue:4 Volume:5 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Gu Jiaqi¹²,Wu Jing¹²,Cao Yuwen¹²,Zou Xinran¹²,Jia Xiaonan¹²,Yin Yiqian¹²,Shen Li³,Fang Daihua⁴,Mao Lingxiang¹^ORCID

Affiliation:

1. Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, China

2. Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China

3. Zhenjiang Center for Disease Control and Prevention, Zhenjiang, Jiangsu, China

4. Clinical Laboratory, Xuzhou Children’s Hospital, Xuzhou, China

Abstract

EV-A71 was supposed to infect the CNS through the neural pathway and the circulation of the blood in previous studies. Reverse axon transport had been confirmed as an important pathway for EV-A71 to infect the CNS; however, it is still unknown how EV-A71 infects the CNS through the circulation of the blood. Combined with the infectivity of sEVs secreted from EV-A71-infected cells and the characteristic that sEVs could cross the blood-brain barrier, we considered that sEVs may play a vital role in EV-A71 pathogenesis of the CNS.

Funder

Jiangsu Province Medical Talents Program

Jiangsu Preventive Medicine Science and Technology Project

National Natural Science Foundation of China

Science and Technology Planning Social Development Project of Zhenjiang City

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00377-20

Reference21 articles.