HIV-1 Infection Alters the Viral Composition of Plasma in Men Who Have Sex with Men

Author:

Liu Kai123,Li Yanpeng3ORCID,Xu Rong12,Zhang Yan4,Zheng Chenli4,Wan Zhenzhou5,Li Hao4,Yang Zhengrong4,Jin Xia3,Hao Pei12,Zhao Jin4,Zhang Chiyu3

Affiliation:

1. Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

2. University of Chinese Academy of Sciences, Shanghai, China

3. Shanghai Clinical Research Center for Infectious Disease (HIV/AIDS), Shanghai Public Health Clinical Center, Fudan University, Shanghai, China

4. Shenzhen Center for Disease Control and Prevention, Shenzhen, China

5. Medical Laboratory of Taizhou Fourth People’s Hospital, Taizhou, China

Abstract

Though an increasing number of studies have indicated the existence of an interaction between the virome and human health or disease, the specific role of these plasma viral components remains largely unsolved. We provide evidence here that an altered plasma virome profile is associated with different immune statuses of HIV-1 infection.

Funder

Shenzhen Key Medical Discipline Construction Fund

Shenzhen Health System Research Project

San-Ming Project of Medicine in Shenzhen

Guangdong Basic and Applied Basic Research Foundation

Shanghai Science and Technology Innovation Action Program

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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