Spatial and Temporal Analysis of the Stomach and Small-Intestinal Microbiota in Fasted Healthy Humans-Reference-Cited by-同舟云学术

Spatial and Temporal Analysis of the Stomach and Small-Intestinal Microbiota in Fasted Healthy Humans

Published:2019-04-24 Issue:2 Volume:4 Page:
ISSN:2379-5042
Container-title:mSphere
language:en
Short-container-title:mSphere

Author:

Seekatz Anna M.¹^ORCID,Schnizlein Matthew K.²^ORCID,Koenigsknecht Mark J.¹³^ORCID,Baker Jason R.⁴,Hasler William L.⁴^ORCID,Bleske Barry E.⁵^ORCID,Young Vincent B.¹²^ORCID,Sun Duxin³

Affiliation:

1. Department of Internal Medicine, Division of Infectious Disease, University of Michigan, Ann Arbor, Michigan, USA

2. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA

3. Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA

4. Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA

5. Department of Pharmacy Practice and Administrative Sciences, University of New Mexico, Albuquerque, New Mexico, USA

Abstract

The gut microbiota are linked to a variety of gastrointestinal diseases, including inflammatory bowel disease. Despite this importance, microbiota dynamics in the upper gastrointestinal tract are understudied. Our article seeks to understand what factors impact microbiota dynamics in the healthy human upper gut. We found that the upper gastrointestinal tract contains consistently prevalent bacterial OTUs that dominate the overall community. Microbiota variability is highest in the stomach and duodenum and correlates with pH.

Funder

U-M | Michigan Institute for Clinical and Health Research

HHS | U.S. Food and Drug Administration

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSphere.00126-19

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