Acinetobacter baumannii Genes Required for Bacterial Survival during Bloodstream Infection

Abstract

A. baumannii is a significant cause of bacterial bloodstream infection in humans. Since multiple antibiotic resistance is becoming more common among strains of A. baumannii , there is an urgent need to develop novel tools to treat infections caused by this dangerous pathogen . To develop knowledge-guided treatment approaches for A. baumannii , a thorough understanding of the mechanism by which this pathogen causes bloodstream infection is required. Here, using a mouse model of infection, we report the identification of A. baumannii genes that are critical for the ability of this pathogen to cause bloodstream infections. This study lays the foundation for future research on A. baumannii genes that can be targeted to develop novel therapeutics against this emerging human pathogen.