Serum Antibody Responses against Carbapenem-Resistant Klebsiella pneumoniae in Infected Patients

Author:

Banerjee Kasturi12ORCID,Motley Michael P.13,Diago-Navarro Elizabeth1,Fries Bettina C.123

Affiliation:

1. Department of Medicine, Infectious Disease Division, Stony Brook University, Stony Brook, New York, USA

2. Veteran’s Administration Medical Center, Northport, New York, USA

3. Department of Molecular Genetics and Immunology, Stony Brook University, Stony Brook, New York, USA

Abstract

Carbapenem-resistant Klebsiella pneumoniae is a rapidly emerging public health threat that can cause fatal infections in up to 50% of affected patients. Due to its resistance to nearly all antimicrobials, development of alternate therapies like antibodies and vaccines is urgently needed.

Funder

HHS | National Institutes of Health

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference47 articles.

1. Systematic review and meta-analysis of mortality of patients infected with carbapenem-resistant Klebsiella pneumoniae

2. World Health Organization. 2019. WHO publishes global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics. World Health Organization, Geneva, Switzerland. https://www.who.int/medicines/publications/WHO-PPL-Short_Summary_25Feb-ET_NM_WHO.pdf.

3. Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study

4. The diversity of Klebsiella pneumoniae surface polysaccharides

5. wzi Gene Sequencing, a Rapid Method for Determination of Capsular Type for Klebsiella Strains

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